Testosterone in Men
Benefits:
Maintains muscle mass, improves strength and physical performance.
Improves libido and erectile function.
Improves mood.
Increases bone mineral density.
Improves symptoms of coronary artery disease (angina).
Decreases total cholesterol and LDL.
Possible Side Effects and Risks:
Decreases HDL.
Increases clotting factors.
Increases Hemoglobin production.
Increases risk of heart attack and death in men over 65.
Increased PSA and prostate volume.
May decrease testicular size and decrease sperm production.
Studies to date have not demonstrated a link between testosterone replacement therapy and prostate cancer.
Contraindications for Testosterone Therapy:
Breast or prostate cancer
Palpable prostate nodule or swelling
PSA greater than 4 or greater than 3 in men at high risk for prostate cancer
such as African-Americans or men with first-degree relatives with prostate cancer
Hematocrit greater than 50%
Untreated severe obstructive sleep apnea
Severe lower urinary tract symptoms
Increase risk for heart disease in men over age 65
Uncontrolled or poorly controlled heart failure.
DHEA
DHEA, the most abundant hormone in the body, is a steroid hormone produced naturally in the adrenal glands, testicles, and brain. Clinical studies have shown that DHEA (dehydroepiandrosterone) has a profound effect on the immune system, sex drive, metabolism, and emotional stability. Its effects on the ·immune system, via the modulation of stress hormones and its use as a powerful antioxidant, demonstrate potent age-resisting capabilities. Other health related benefits include the ability to alter cognitive decline, to help the body cope with stress, and to exert a healthy influence over. The heart via cholesterol modulation.
Benefits:
Improves insulin sensitivity
Improves body composition by reducing abdominal fat and weight.
Improves blood flow
Improves cellular immunity
Improves bone metabolism, may improve osteoporosis in older men and women
Improves sexual function including libido and erectile dysfunction in men
Improves physical strength in frailty
Reduces inflammation
Provides neuroprotection (protects brain cells)
Improves cognitive function, and memory enhancement
Improves symptoms of depression
Decreases the effects of aging on skin
Decreases the severity of lupus and may help chronic fatigue syndrome
Modulates endothelial function.
Possible Side Effects and Risks:
Side effects have only been described when high doses of DHEA have been used i.e. greater than 200mgs/day, raising DHEAS level$ to beyond physiological levels.
In women: acne, male pattern hair loss or growth, menstrual irregularities, headaches, insomnia
In men: more prominent breasts (gynecomastia), breast tenderness, increased blood pressure, testicular wasting, or increased aggressiveness.
May lower HDL (good cholesterol)
There is theoretical concern that long-term use or use of amounts that cause higher than normal physiological DHEA levels might increase the risk of prostate cancer, breast cancer, or other hormone-sensitive cancers.
In diabetes, blood sugars need to be closely monitored
Contraindications for DHEA Therapy
Breast cancer, uterine cancer, ovarian cancer, endometriosis, and uterine fibroids or prostate cancer.
Liver disease
